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GlutaminePlus is an alternative to L-glutamine that can improve cell viability and growth. It is used as an effective substitute for L-glutamine in cell culture media.
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Normal L-glutamine has a relatively short half-life in solution, showing a temperature-dependent loss of product with time. L-glutamine degrades through an intramolecular cyclization reaction forming as by-products, pyrrolidone carbonic acid and ammonia in equimolar concentrations. The rate of breakdown increases with increasing temperature and in the presence of phosphate or bicarbonate.
Dipeptide derivatives of L-glutamine prevent the intramolecular cyclization reaction associated with solutions of L-glutamine. These derivatives are therefore stable in solution and allow the formulation of cell culture media containing L-glutamine that may be stored at 4C for extended periods. Solutions containing these derivatives can even be autoclaved without appreciable degradation of the product (30 minutes at 121C results in approximately <5% loss of the product).
The dipeptide derivatives are metabolized within the cells to yield L-glutamine plus the second amino acid. This results in more consistent delivery of L-glutamine to cells in culture and avoids toxic buildup of ammonia in cell cultures. This feature can be especially important for ammonia sensitive cell lines.
- Molecular weight: 217.22
- Form: Powder
- Product Size: 100 gm
- Quality Testing: Pass
- Suitability: Laboratory research applications
- Shipping conditions: Ambient
- Storage conditions: Room temperature, under dry conditions